Preclinical Safety
Assessment of AAVs:
Magnetic Resonance Imaging (MRI) Guided Intracranial
Dosing of African Green Monkeys (AGM)
Gene therapy holds immense promise for treating various neurological disorders, but ensuring its safety and efficacy requires rigorous preclinical research. Our scientific poster delves into the vital role of African green monkeys (AGMs) and cynomolgus macaques in this process. Learn about the innovative techniques employed for central administration of therapeutic agents and the implications of our findings for advancing gene therapy development.
Our scientific poster provides invaluable insights into the utilization of AGMs and cynomolgus macaques in preclinical research, shedding light on the intricate processes involved in gene therapy development and the crucial role of animal models in advancing medical science.
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Explore our scientific poster comparing intraocular pressure (IOP) in African green monkeys (AGM) to macaques. Gain validated reference values, insights into sedation influences, and practical implications for ocular research.
At Virscio, we leverage groundbreaking research like this to conduct preclinical studies that pave the way for novel gene therapies. Our commitment to excellence in research enables us to drive innovation and accelerate the development of life-changing treatments for neurological disorders.
In this scientific poster, you will learn more about:
- The seroprevalence of neutralizing antibodies to different AAV serotypes in AGMs.
- Techniques for MRI-guided intracranial dosing procedures.
- The importance of AGMs as a model for preclinical safety assessments in gene therapy.
- Insights into the successful administration of therapeutic agents in nonhuman primates.
- Practical implications for supporting multiple development programs in gene therapy.
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